| Through Week 14 of 2024 Season | ||||||||
| Single | ||||||||
| Season | Career | |||||||
| Rank | Name | Year | Interceptions | Rank | Name | Years | Interceptions | |
| 1 | Brad Hausfeld | 1971 | 11 | 1 | Doug Rutschilling | 1987 - 1989 | 19 | |
| Doug Rutschilling | 1989 | 11 | 2 | Rick Albers | 1980 - 1983 | 18 | ||
| 3 | Rick Albers | 1983 | 8 | 3 | James Niemeyer | 2021 - 2023 | 14 | |
| James Niemeyer | 2022 | 8 | 4 | Ben Ernst | 1988 - 1989 | 13 | ||
| 5 | Bob Fortman | 1984 | 7 | 5 | Brad Hausfeld | 1970 - 1971 | 12 | |
| Ben Ernst | 1988 | 7 | Jacob Dues | 2013 - 2015 | 12 | |||
| Austin Brown | 2017 | 7 | Jonathan Niemeyer | 2014 - 2016 | 12 | |||
| Mike Ketner | 2018 | 7 | 8 | Bob Fortman | 1982 - 1984 | 10 | ||
| 9 | Rick Albers | 1982 | 6 | Jared Huelsman | 2015 - 2017 | 10 | ||
| Doug Rutschilling | 1988 | 6 | Mike Ketner | 2017 - 2018 | 10 | |||
| Ben Ernst | 1989 | 6 | Connor Schmiesing | 2021 - 2024 | 10 | |||
| Robert Gruber | 2008 | 6 | 12 | Korey Schultz | 2011 - 2012 | 9 | ||
| Jonathan Niemeyer | 2015 | 6 | Austin Brown | 2017 - 2018 | 9 | |||
| Alex Lehmkuhl | 2017 | 6 | 14 | Ben Schemmel | 1990 - 1992 | 8 | ||
| 15 | Greg Lampert | 1979 | 5 | Scott Winner | 1995 - 1997 | 8 | ||
| Mark Oldiges | 1984 | 5 | Alex Lehmkuhl | 2016 - 2017 | 8 | |||
| Troy Parks | 2005 | 5 | 17 | Terry Griner | 1972 - 1975 | 7 | ||
| Jay Eilerman | 2011 | 5 | Ron Boeke | 1973 - 1975 | 7 | |||
| Korey Schultz | 2012 | 5 | Jeff Stucke | 1989 - 1990 | 7 | |||
| Jacob Dues | 2013 | 5 | Steve Prenger | 1990 - 1992 | 7 | |||
| Jacob Dues | 2015 | 5 | Zac Boeke | 2004 - 2006 | 7 | |||
| Connor Schmiesing | 2023 | 5 | Robert Gruber | 2007 - 2008 | 7 | |||
| Caleb Couse | 2024 | 5 | Devon Poeppelman | 2009 - 2012 | 7 | |||
| 24 | Ron Boeke | 1975 | 4 | Jared Thobe | 2014 - 2015 | 7 | ||
| John Heitbrink | 1981 | 4 | 25 | Greg Lampert | 1979 - 1981 | 6 | ||
| Allen Mescher | 1986 | 4 | Mark Oldiges | 1983 - 1984 | 6 | |||
| Mark Prenger | 1987 | 4 | Allen Mescher | 1984 - 1986 | 6 | |||
| Jeff Stucke | 1989 | 4 | Eric Belcher | 1991 - 1993 | 6 | |||
| Jason Woehrmyer | 1989 | 4 | Troy Parks | 2003 - 2005 | 6 | |||
| Brian Wuebker | 1989 | 4 | Austin Knapke | 2009 - 2011 | 6 | |||
| Justin Sommer | 1991 | 4 | Paul Dues | 2011 - 2013 | 6 | |||
| Eric Belcher | 1991 | 4 | Eli Wolf | 2013 - 2014 | 6 | |||
| Ben Schemmel | 1991 | 4 | Isaac Schmiesing | 2016 - 2017 | 6 | |||
| Steve Prenger | 1992 | 4 | Chase Couse | 2020 - 2022 | 6 | |||
| Scott Winner | 1996 | 4 | 35 | Jay Eilerman | 2011 | 5 | ||
| Brian Homan | 1996 | 4 | Caleb Couse | 2024 | 5 | |||
| Jim Dwenger | 1999 | 4 | Chuck Meyer | 1984 - 1986 | 5 | |||
| Marc Stueve | 2001 | 4 | Matt Quinter | 1997 - 1998 | 5 | |||
| Zac Boeke | 2005 | 4 | Alex Stricker | 2002 - 2004 | 5 | |||
| Reid Heitkamp | 2008 | 4 | Dane Sommer | 2002 - 2004 | 5 | |||
| Troy Kauffman | 2011 | 4 | Devan Wuebker | 2020 - 2022 | 5 | |||
| Korey Schultz | 2011 | 4 | Noah Schwieterman | 2022 - 2023 | 5 | |||
| Jared Thobe | 2014 | 4 | 43 | John Heitbrink | 1981 | 4 | ||
| Jared Huelsman | 2015 | 4 | Mark Prenger | 1987 | 4 | |||
| Jonathan Niemeyer | 2016 | 4 | Brian Wuebker | 1989 | 4 | |||
| Jared Huelsman | 2017 | 4 | Jason Woehrmyer | 1989 | 4 | |||
| Isaac Schmiesing | 2017 | 4 | Justin Sommer | 1991 | 4 | |||
| Kody Richards | 2019 | 4 | Brian Homan | 1996 | 4 | |||
| Kole Richard | 2024 | 4 | Jim Dwenger | 1999 | 4 | |||
| 50 | Roger Meyer | 1969 | 3 | Marc Stueve | 2001 | 4 | ||
| Ron Boeke | 1973 | 3 | Reid Heitkamp | 2008 | 4 | |||
| Mark Cordonnier | 1974 | 3 | Troy Kauffman | 2011 | 4 | |||
| Tim Schmiesing | 1976 | 3 | Kody Richards | 2019 | 4 | |||
| Bob Fortman | 1982 | 3 | Kole Richard | 2024 | 4 | |||
| Dave Oldiges | 1984 | 3 | Jay Hogenkamp | 1955 - 1957 | 4 | |||
| Chuck Meyer | 1984 | 3 | Dan Westerheide | 1974 - 1975 | 4 | |||
| Rex Mescher | 1987 | 3 | Dave Oldiges | 1983 - 1984 | 4 | |||
| Toby Meyer | 1988 | 3 | Randy Stueve | 1987 - 1988 | 4 | |||
| Steve Prenger | 1990 | 3 | Brian Heitkamp | 1993 - 1994 | 4 | |||
| Jeff Stucke | 1990 | 3 | P.J. Seiter | 1994 - 1995 | 4 | |||
| Ben Schemmel | 1990 | 3 | Adam Clune | 1995 - 1996 | 4 | |||
| Brian Heitkamp | 1994 | 3 | Chris Brown | 2000 - 2001 | 4 | |||
| P.J. Seiter | 1995 | 3 | Dean Ripploh | 2003 - 2004 | 4 | |||
| Adam Clune | 1996 | 3 | Sam Otting | 2007 - 2008 | 4 | |||
| Scott Winner | 1997 | 3 | August Boehnlein | 2016 - 2017 | 4 | |||
| Matt Quinter | 1997 | 3 | Adam Ketner | 2019 - 2020 | 4 | |||
| James Sharp | 1998 | 3 | Will Knapke | 2022 - 2023 | 4 | |||
| Chris Brown | 2001 | 3 | 68 | Roger Meyer | 1969 | 3 | ||
| Justin Gusching | 2002 | 3 | Mark Cordonnier | 1974 | 3 | |||
| Dean Ripploh | 2004 | 3 | Tim Schmiesing | 1976 | 3 | |||
| Alex Stricker | 2004 | 3 | Rex Mescher | 1987 | 3 | |||
| Bryan Phlipot | 2008 | 3 | Toby Meyer | 1988 | 3 | |||
| Devon Poeppelman | 2010 | 3 | James Sharp | 1998 | 3 | |||
| Austin Knapke | 2011 | 3 | Justin Gusching | 2002 | 3 | |||
| Paul Dues | 2012 | 3 | Bryan Phlipot | 2008 | 3 | |||
| Devon Poeppelman | 2012 | 3 | Noah Enneking | 2018 | 3 | |||
| Eli Wolf | 2013 | 3 | Brendan Bornhorst | 2019 | 3 | |||
| Eli Wolf | 2014 | 3 | Ted Frericks | 1953 - 1956 | 3 | |||
| Jared Thobe | 2015 | 3 | Jon Meyer | 1969 - 1971 | 3 | |||
| Mike Ketner | 2017 | 3 | Dan Moorman | 1971 - 1972 | 3 | |||
| August Boehnlein | 2017 | 3 | Craig Sherman | 1974 - 1975 | 3 | |||
| Noah Enneking | 2018 | 3 | Steve Eiting | 1984 - 1985 | 3 | |||
| Brendan Bornhorst | 2019 | 3 | Jeff Roetgerman | 1985 - 1986 | 3 | |||
| Adam Ketner | 2019 | 3 | Bill Oldiges | 1988 - 1990 | 3 | |||
| Chase Couse | 2022 | 3 | Corey Borgert | 1990 - 1991 | 3 | |||
| Devan Wuebker | 2022 | 3 | Brad Heitkamp | 1993 - 1994 | 3 | |||
| Noah Schwieterman | 2023 | 3 | Keith Nerderman | 2006 - 2007 | 3 | |||
| 88 | Virgil Huelskamp | 1951 | 2 | Chase Paxson | 2009 - 2010 | 3 | ||
| Ted Frericks | 1953 | 2 | Jacob Stechschulte | 2013 - 2015 | 3 | |||
| Jon Hogenkamp | 1953 | 2 | Carter Hogenkamp | 2015 - 2016 | 3 | |||
| Mike Connaughton | 1954 | 2 | Alex Schmitmeyer | 2018 - 2019 | 3 | |||
| Jay Hogenkamp | 1955 | 2 | 92 | Virgil Huelskamp | 1951 | 2 | ||
| Jay Hogenkamp | 1957 | 2 | Jon Hogenkamp | 1953 | 2 | |||
| Bob Zimmerer | 1959 | 2 | Mike Connaughton | 1954 | 2 | |||
| Bob Fischer | 1965 | 2 | Bob Zimmerer | 1959 | 2 | |||
| John Dues | 1970 | 2 | Bob Fischer | 1965 | 2 | |||
| Dan Moorman | 1971 | 2 | John Dues | 1970 | 2 | |||
| Terry Griner | 1973 | 2 | Jeff Lampert | 1978 | 2 | |||
| Terry Griner | 1974 | 2 | Greg Heitkamp | 1982 | 2 | |||
| Dan Westerheide | 1974 | 2 | Tony Enneking | 1985 | 2 | |||